Ketoconazole Coadministration of bosentan one hundred twenty five mg 2 times each day and ketoconazole, a strong CYP3A inhibitor, amplified the plasma concentrations of bosentan by approximately 100% in ordinary volunteers. No dose adjustment of bosentan is critical, but increased effects of bosentan should be viewed as. Variation assessment report https://kameronzyskb.blogerus.com/48621069/an-unbiased-view-of-bosentan